Basic Fact by Opsimath

Puzzle explanation

The highlighted parts in the grid were a traditional description of an acid-alkali neutralisation reaction: ACID + ALKALI = SALT & WATER. The preamble specified three different symbols, so SALT + WATER was not accepted.

Clue explanations

Conventions: * = anagram, < = reversal

No Answer Explanation
Across
1 AS NOW A + SNOW
5 PREMIER CRU (CUP + MERRIER) *
12 CAESAR homophone of SEIZER
13 EPHEMERON EN around (HER POEM) *
14 PLUSHLY PLY around LUSH
18 DRUNKS RUN in DK’S
20 ONION DOME ONION + DOME
24 COEQUALS SQUEAL * after CO
25 WIDOWER WI + DOWER
26 ROTOLOS (SO + LOT + OR) <
27 ITS (v)I(s)T(a)S
28 EARLINESS EAR + LINES + S
30 TAMANDUA (A MAD AUNT) *
34 CLIO CLI + O
35 KERMESITE (MEET SKIER) *
36 ATTUNE A + TT + UNE
37 SLENDEREST (ELDERS SENT) *
38 OTTAR (t)RATTO(ria) <
Down
1 ACID FREAKS AF around CID + REAKS
2 SAIR SA + IR
3 NE PLUS ULTRA SUPERNATURALLY * − RAY *
4 WALK W + A + L(oo)K
5 PRY PRIVACY − (I + VAC)
6 RENO ONER <
7 MHO M(ilitary) H(ousehold) O(fficers)
8 EMENDS EM + ENDS
9 RED DOG DODGER *
10 ROAMED (c)OMRADE *
11 UNDERWATER ’UN + DERWENTWATER − WENT
15 UNEQUALS QU in (NE + AL) in US
16 MOIST MAOIST − A
17 DOWN-AND-OUT (ODD AUNT NOW) *
19 SCONE SC + ON + E
21 BOATEL (n)OTABLE(s) *
22 SOLEMN SOL + EMIN − I
23 ALIPED (I PEDAL) *
27 ISA 3 meanings
29 SUES (tenni)S after SUE
31 ALTO ALT + O
32 ULNA (painf)UL NA(ils)
33 MIR MIR(in)
34 CAT CA + T; ref. Van cat variety
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